PPARα Modulates Acrolein‐Induced Inflammatory Signaling in gp91phox Knock‐Out Mice
نویسندگان
چکیده
منابع مشابه
Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice.
BACKGROUND Oxidative stress largely contributes to early brain injury after subarachnoid hemorrhage (SAH). One of the major sources of reactive oxygen species is NADPH oxidase, upregulated after SAH. We hypothesized that NADPH oxidase-induced oxidative stress plays a major causative role in early brain injury after SAH. METHODS Using gp91phox knockout (ko) and wild-type (wt) mice, we studied ...
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BACKGROUND AND AIMS Monoglyceride lipase (MGL) catalyzes the final step of lipolysis by degrading monoglyceride (MG) to glycerol and fatty acid. MGL also hydrolyzes and thereby deactivates 2-arachidonoyl glycerol (2-AG), the most abundant endocannabinoid in the mammalian system. 2-AG acts as full agonist on cannabinoid receptor type 1 (CB1R) and CB2R, which are mainly expressed in brain and imm...
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Physical exercise promotes glucose uptake into skeletal muscle and makes the working muscles more sensitive to insulin. To understand the role of insulin receptor (IR) signaling in these responses, we studied the effects of exercise and insulin on skeletal muscle glucose metabolism and insulin signaling in mice lacking insulin receptors specifically in muscle. Muscle-specific insulin receptor k...
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AIMS/HYPOTHESIS In uncoupling protein-2 (UCP2) knockout (KO) mice, protection of beta cells from fatty acid exposure is dependent upon transcriptional events mediated by peroxisome proliferator-activated receptor-alpha (PPARalpha). METHODS PPARalpha expression was reduced in isolated islets from UCP2KO and wild-type (WT) mice with siRNA for PPARalpha (siPPARalpha) overnight. Some islets were ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.1142.7